Involvement of Alpha7 nAC hR downregulation in rat oxaliplatin-induced neuropathy

Lorenzo Di Cesare Mannelli, Laura Bonaccini, Matteo Zanardelli, Tommaso Mello, Alessandra Pacini & Carla Ghelardini
Oxaliplatin, unlike other platinum derivatives, does not result in significant renal impairment or ototoxicity, and it has only mild hematological and gastrointestinal toxicity. On the other hand the limiting side effect is its neurotoxicity that acts as bases for a neuropathic syndrome. A tangled panel of symptoms may be disabling for these patients, adversely affecting activities of daily living and thereby quality of life. In a rat model of painful oxaliplatin-induced neuropathy, we are describing...
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