BBB-endothelial cell response to cerebral cortex demyelination in a mouse model of chronic EAE

Mariella Errede, Maurizio Strippoli, Francesco Girolamo, Marco Rizzi, Luisa Roncali & Daniela Virgintino
Changes in blood-brain barrier (BBB) function have been implicated in demyelinating diseases. This study aimed to investigate the response of cerebral cortex microvessels to nerve fibre demyelination in a chronic model of murine experimental autoimmune encephalomyelitis (EAE) characterized by areas of extensive subpial demyelination along with well-demarcated lesions extended to deeper cortex layers. These cortices showed activation of microglia and astrogliosis with absence of typical perivascular inflammatory infiltrates. On the basis of these data, we...
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