Thrombin receptor PAR-1 is a glial cell receptor involved in the regeneration of peripheral nerves

Cinzia Fabrizi, Elena Pompili, Francesca Somma & Lorenzo Fumagalli
Thrombin, a multifunctional serine protease, is a key enzyme in the coagulation cascade. Most of its actions are mediated by a G protein-coupled protease activated receptor (PAR-1) which is highly expressed in glial cells especially after injury (Pompili et al., 2006; Pompili et al., 2011) . In the peripheral nerves thrombin and PAR-1 specific agonist peptides produce changes in nerve conduction compatible with a conduction block. Aim of the present study is to determine if...
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