Inflammatory effect of sputum microparticles derived from pulmonary diseases in a murine model

Chiara Porro, Teresa Trotta, Silvia Lepore, Anna Laura Colia, Sante Di Gioia, Maria Antonietta Panaro, Massimo Conese & Angela Bruna Maffione
Microparticles (MPs) are small plasma membrane vesicles released by several cell types (macrophages, platelets, endothelial cells, granulocytes, monocytes, lymphocytes) following chemical, physical and apoptotic stimuli. MPs bear a number of bioactive effectors that can be disseminate, exchanged, and transferred via MPs cell interactions. The hallmarks of lung disease in cystic fibrosis (CF) patients are a persistent infection with opportunistic bacterial pathogens such as the Gram-negative P. aeruginosa and an abnormal inflammatory response dominated by polymorphonuclear...
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