Ameliorative effect of PACA P and VIP against increased permeability in a model of outer blood retinal barrier

Soraya Scuderi, Agata Grazia D’Amico, Alessandro Castorina, Rosa Imbesi, Paola Castrogiovanni & Velia D’Agata
Diabetic retinopathy (DR) is one of the leading causes of blindness and vision loss in adults. A recent study has demonstrated that compromised tight junctions, basement membrane thickening and increased vascular permeability contribute to the disruption of the outer blood-retinal barrier (BRB) in DR. The outer BRB is formed by retinal pigmented epithelial cells and controls the flow of solutes and fluid from the choroidal vasculature to the outer retina. Previous studies have shown that...
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