Differentiation of Mesenchymal Stem Cells towards an insulin-releasing phenotype after co-culture with Pancreatic Islets

Arianna Scuteri, Elisabetta Donzelli, Virginia Rodriguez-Menendez, Maddalena Ravasi, Barbara Bonandrini, Marina Figliuzzi, Andrea Remuzzi & Giovanni Tredici
Transplantation of pancreatic islets has become a promising clinical option to treat patients with type 1 diabetes, alternative to the standard therapy with insulin injections. Islet transplantation is a minimally invasive therapeutic approach, and it allows a better metabolic control and a long-term insulin independence in more than 80% of patients (Ryan et al., 2002). However this therapeutic treatment has some side effects, such as the poor yield of pancreatic islet explants and even more...
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