Frequent hypomethylation of PTGS2 gene promoter in human term placenta

Nuruddin Mohammad, Ahmed Yaqinuddin, Fatima Kakal, Luman Sheikh, Rahat Qureshi & Mehreen Somani
Background: Gene expression profiles of several tumor suppressor genes are regulated by the methylation and demethylation of their promoters. Here, we aim to identify and quantify the methylation status of four tumor suppressor genes from placentas at term and compare them with the maternal white-blood-cells. Methods: In order to achieve this objective, DNA enriched from twenty placentas at term and maternal white blood cells was bisulfite-converted and amplified using quantitative real-time methyl-light polymerase chain reaction...
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