Acute treatment with relaxin attenuates the injury/ dysfunction induced by renal ischemia/reperfusion injury

Massimo Collino, Mara Rogazzo, Alessandro Pini, Elisa Benetti, Arianna Carolina Rosa, Roberto Fantozzi, Daniele Bani & Emanuela Masini
Although preclinical and clinical studies have demonstrated that relaxin (RLX) ameliorates impaired renal function by exerting antifibrotic and regenerative effects, its role in renal ischemia/reperfusion (I/R) injury has never been investigated. Using a well-known rat model of 1h bilateral renal artery occlusion followed by 6 h reperfusion, we investigated the effects of human recombinant RLX (5 μg /Kg e.v.) given both at the beginning and after 3 h reperfusion. Serum and urinary indicators of renal...
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