Dopamine D3 receptor knockout mice exhibit increased hippocampal cAMP response element binding protein (CREB) following acquisition of passive avoidance memory

Agata Grazia D’Amico, Alessandro Castorina, Gian Marco Leggio, R. Imbesi, Filippo Drago & Velia D’Agata
The dopamine D3 (D3R) receptor seems to be implicated in synaptic plasticity and memory-related processes as identified by several pharmacological and behavioral approaches (Laszy et al., 2005; Swant 2008). In a previous study we have shown that D3Rs mediate an inhibitory effect on learning, since D3R knockout (D3-/-) mice display enhanced cognitive performance in the single trial step-through passive avoidance task (PA) as compared to WTs (Micale et al., 2010; D’Amico et al., 2013). Formation...
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