Understanding muscle stem cell regenerative decline with aging

Pura Muñoz-Cánoves
Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident Pax7-expressing stem cells (satellite cells), which are normally quiescent in the adult. Upon injury, quiescent satellite cells activate and proliferate, to subsequently differentiate and form new myofibers or self-renew to restore the quiescent satellite cell pool. Through a combination of global gene expression/bioinformatics and molecular/cellular assays, we found that resting satellite cells have basal autophagy activity, which is required to maintain the...
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