The Organ Care System as a new promising tool for donor heart ex vivo preservation

Antonella Bonetti, Giovanni Benedetti, Cristina Cantarutti, Veronica Ferrara, Magali Contin, Nicoletta Finato, Sandro Sponga, Gennaro Esposito, Ugolino Livi & Fulvia Ortolani
Heart transplantation remains the gold standard treatment for end-stage heart failure. To face actual donor shortage, heart warm perfusion with the Organ Care System (OCS) was introduced alternatively to usual cold ischemic storage [1]. Here, OCS-preserved hearts were matched against those subjected to cold ischemia in terms of (i) perioperative clinical parameters, (ii) histopathological, immunohistochemical, and ultrastructural features of pre- and post-implant left ventricle biopsies, and (iii) cardiomyocyte metabolism by NMR spectroscopy of blood samples....
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