Effects of the endoplasmic reticulum signaling pathway on cadmium-induced impairment of the blood brain barrier

Jacopo J.V. Branca, Mario Maresca, Gabriele Morucci, Ferdinando Paternostro, Lorenzo Di Cesare Mannelli, Massimo Gulisano & Alessandra Pacini
Due to its high permeability to blood-brain barrier (BBB), cadmium (Cd) has been regarded as a possible etiological factor for human neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease [1]. However, the mechanism underlying cadmium-induced BBB permeability remains unclear. In this study, we investigated the effect of Cd in RBE4 cells (rat brain endothelial cells) and delineated the signaling pathway that, triggering endoplasmic reticulum (ER) stress and caspase 3 activation, leads to...
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