Stress proteins in experimental nephrotoxicity: a ten year experience

Alessandra Stacchiotti, Francesca Bonomini, Gaia Favero, Claudia Rossini, Luigi F. Rodella & Rita Rezzani
Heat shock proteins and glucose­regulated proteins represent an extraordinary mechanism of defense induced in the kidney by chemicals or drugs and essential to survive. Here we resume our experience on the presence and regulation of stress proteins into acute and chronic nephrotoxic models in rodents and in vitro.
In acute renal damage, induced in rats by a single injection of inorganic mercury, stress proteins enhanced in a dose-dependent manner to recover cytoskeleton and mitochondria and...
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