Identification of nuclear substrates of Akt/PKB by functional proteomics: prohibitin 2 is a target of Akt phosphorylation in human promyelocytic leukemia cells

Alberto Bavelloni, Irene Faenza, Manuela Piazzi, William Blalock, Antonietta D’Angelo, Francesca Tagliavini, Diego Pinetti, Sandro Matteucci, Giulia Adalgisa Mariani & Lucio Cocco
The serine/threonine protein kinase Akt is a major signal transducer of the phosphoinositide 3-kinase (PI 3-K) pathway in all cells and tissues and plays a pivotal role in the maintenance of cellular processes including cell growth, proliferation, survival, metabolism and development of many malignancies including acute myeloid leukemia. The frequent aberrant activation of the PI 3-K/Akt pathway in human cancer has made it an attractive therapeutic target. Therefore, the study of effector proteins downstream of...
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