Hepatic progenitor cells as a source of adipokines and glucagon-like peptide-1 in pediatric nonalcoholic fatty liver disease

Guido Carpino, Valerio Nobili, Paolo Onori, Anna Alisi, Antonio Franchitto, Rita De Vito, Romina Mancinelli, Gianfranco Alpini, Domenico Alvaro & Eugenio Gaudio
Background & aims. nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of liver-related morbidity and mortality in children. NAFLD includes a spectrum of diseases ranging from simple fatty liver to nonalcoholic steatohepatitis (NASH)1. NASH development is characterized by intricate interactions between resident and recruited cells2. The aim of our study was to evaluate the involvement of Hepatic Progenitor Cells (HPCs) in pediatric NAFLD. Methods. 20 untreated, consecutive children and adolescents with...
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