Expression, distribution and glutamate uptake activity of excitatory aminoacid transporters in vitro cultures of embryonic rat dorsal root ganglia cells

Guido Cavaletti, Valentina Carozzi, Gabriella Nicolini, Giovanni Tredici & Paola Marmiroli
Glutamate is the major mediator of excitatory signalling in the mammalian central nervous system, but it has recently been shown to play also a role in the transduction of sensory input at the periphery and in peripheral neuropathies. New advances in research have demonstrated that rat peripheral sensory terminals and dorsal root ganglia (DRG) express molecules involved in glutamate signalling, including high-affinity membrane-bound glutamate transporters (Excitatory Aminoacid Transporters, EAATs) and that alterations in their expression...
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