In Vitro toxicological effects of Fumonisin B1 and Beauvericin on bovine granulosa cells

Marco Albonico, Leon Spicer, Cristina Cortinovis, Luis Fernando Schutz & Francesca Caloni
Fumonisin B1 (FB1) and beauvericin (BEA) are fusariotoxins found to co-exist in food and feed commodities. The aim of this study is to evaluate the individual and combined effects of FB1 and BEA on bovine granulosa cell proliferation and steroid production. Granulosa cells (GC) from small bovine follicles (1-5 mm) were cultured for 48 hours in 10% fetal bovine serum followed by 48 hours in a serum-free medium containing 500 ng/ml of testosterone (as an...
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