Protein tyrosine phosphatase PRL-3 expression and transcriptional regulation in cancer and metastasis

Patrick Chun Wei Wong
Elevated expression of protein tyrosine phosphatase PRL-3 is implicated in cell migration, invasion, and metastasis, although the molecular targets of this phosphatase remain unidentified. PRL-3 expression is strikingly upregulated in metastatic colon carcinoma, compared with much lower expression in primary colon tumours and virtually undetectable expression in normal colon epithelia. Increased transcriptional activity is suggested to account for increased PRL-3 expression in 75% of the metastatic samples. We used bioinformatics analyses and cell-based promoter assays...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.