Novel genetic effects of a human endogenous retrovirus insertion

Paul Edward Kowalski
Human endogenous retroviruses (HERVs) are repetitive, noninfectious chromosomal elements degenerated from exogenous retroviruses, and compose as much as 2% of the human genome. The HERV-H family numbers approximately 1000 elements dispersed throughout the human genome. HERV-H elements have been shown to affect the expression of adjacent cellular genes. For example, in teratocarcinoma cell lines, a HERV-H LTR promotes expression of, and splices into a downstream cellular transcript, PLA2L, which contains two phospholipase A₂ (PLA₂)-like domains....
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