Age-dependent differences in the transcriptional profile of antigen presenting cells in response to immune stimulation and infection converge on interferon response factors

Kathleen Wee
Newborns and older adults aged 65 and over have a heightened risk for severe infections, suggesting suboptimal immune responses. These two populations thus represent age-defined windows of vulnerability to infection. Antigen presenting cells (APC) are important in bridging the innate and adaptive immune systems as they express pathogen recognition receptors such as Toll-like receptors (TLR) that detect the presence of pathogens. They have been proposed to be partially responsible for the altered immunity observed at...
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