Mathematical Modeling of the Immune-Mediated Theory of Metastasis

Thomas Hillen
Accumulating experimental and clinical evidence suggests that the immune response to cancer is not exclusively anti-tumor. In fact, several pro-tumor effects of the immune system have been identified, such as production of growth factors, establishment of angiogenesis, inhibition of immune response, initiation of cell movement and metastasis, and establishment of metastatic niches. Based on experimental data, we develop a mathematical model for the immune-mediated theory of metastasis, which includes anti- and pro-tumor effects of the...
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