Neural Crest Cell Migration and Tissue Dynamics During Vertebrate Embryogenesis

Paul Kulesa
The neural crest offer a unique model system to study mechanisms of cell migration since cells are accessible to in vivo imaging and manipulation. Although cranial neural crest cells travel through dense extracellular matrix and mesoderm during vertebrate morphogenesis, very little is known how head tissue dynamics effect neural crest cell migratory behaviors. Here, we examine the relationship between neural crest cell and head mesoderm tissue dynamics using time-lapse imaging, computational modeling, and experimental manipulations...
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