PDGFRα+ and HIC1+ mesenchymal progenitors in murine skeletal tissue ; roles in homeostasis and regeneration

Christine Eisner
Despite its rigid structure, bone is a highly dynamic tissue that is constantly remodeled throughout life to maintain its structure and function. Remodeling is mediated by bone resorbing osteoclasts and bone depositing osteoblasts. While the hematopoietic origins of osteoclasts are well understood, the identity of the skeletal mesenchymal progenitors that give rise to osteoblasts remains elusive. Understanding the identity and biology of these skeletal mesenchymal progenitors is critical to the development of therapeutics for the...
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