Structural Heterogeneities of the Ribosome: New Frontiers and Opportunities for Cryo-EM

Frédéric Poitevin, Artem Kushner, Xinpei Li & Khanh Dao Duc
The extent of ribosomal heterogeneity has caught increasing interest over the past few years, as recent studies have highlighted the presence of structural variations of the ribosome. More precisely, the heterogeneity of the ribosome covers multiple scales, including the dynamical aspects of ribosomal motion at the single particle level, specialization at the cellular and subcellular scale, or evolutionary differences across species. Upon solving the ribosome atomic structure at medium to high resolution, cryogenic electron microscopy...
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