Investigating the assembly and function of the bacterial injectisome by hybrid structural methods

Dorothy Diana Majewski
The bacterial injectisome is an essential virulence factor for many Gram-negative pathogens. Resembling a 50-100 nm long syringe, the injectisome creates a continuous channel between the bacterial and host cytosols through which the bacterium secretes effector proteins to modulate host signalling. The aim of the following work is to contribute to the structural characterization of the injectisome, focusing on proteins involved in its assembly and substrate selection. The outer membrane pore of the injectisome, termed...
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