Alumination of Aryl Methyl Ethers: Switching Between sp2 and sp3 C–O Bond Functionalisation with Pd-Catalysis

Feriel Rekhroukh
The reaction of [{(ArNCMe)2CH}Al] (Ar = 2,6-di-iso-propylphenyl, 1) with aryl methyl ethers proceeded with alumination of the sp3 C–O bond by a presumed SN2 pathway. The selectivity of this reaction could be switched by inclusion of a catalyst. In the presence of [Pd(PCy3)2], chemoselective sp2 C–O bond functionalisation was observed. Kinetic isotope experiments and DFT calculations support a catalytic pathway involving the ligand-assisted oxidative addition of the sp2 C–O bond to a Pd---Al intermetallic complex....
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.