Developmental transformation and reduction of connective cavities within the subchondral bone

Shahed Taheri, Thomas Winkler, Lia Sabrina Schenk, Carl Neuerburg, Sebastian Felix Baumbach, Jozef Zustin, Wolfgang Lehmann & Arndt Friedrich Schilling
It is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evaluations of healthy vs. early OA or early OA vs. advanced OA cases, while neglecting how pure maturation could change the SCB’s microstructure. To assess the transformations of the healthy SCB from young age to early...
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