Discovery of intramolecular signal transduction network based on a new protein dynamics model of energy dissipation

Cheng-Wei Ma, Zhi-Long Xiu & An-Ping Zeng
A novel approach to reveal intramolecular signal transduction network is proposed in this work. To this end, a new algorithm of network construction is developed, which is based on a new protein dynamics model of energy dissipation. A key feature of this approach is that direction information is specified after inferring protein residue-residue interaction network involved in the process of signal transduction. This enables fundamental analysis of the regulation hierarchy and identification of regulation hubs...
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