Product-property guided scale-up of a fluidized bed spray granulation process using the CFD-DEM method

Paul Kieckhefen, Swantje Pietsch-Braune & Stefan Heinrich
In this work, a method to predict the surface structures of particles produced by fluidized bed spray layering granulation using the CFD-DEM method was developed. A simple state-variable/event tracking approach was implemented to capture indirect quantifiers of the progression of structure-forming microprocesses. The state of the droplet at the time of impact on the particle surface, as well as the time required for drying, is correlated to product properties that quantify surface structure morphology such...
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