The Evaluation of multiple clinical endpoints, with application to asthma

Markus Neuhäuser, Volker W. Steindans & Frank Bretz
The situation where four primary endpoints are classified into two groups is considered, with the clinical objective to show at least one positive effect in each group. This multiple endpoint scenario may be appropriate in clinical asthma trials, with the two groups being pulmonary function variables and patient recorded outcomes. The statistical motivation for the classification is that the within-group correlation is usually higher than the between-group correlation. Three methods for the evaluation of this...
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