Potential therapeutic alternatives for smokers with osteoarthritis – an in vitro study for preclinical application

Tao Chen
Although the adverse effects of smoking for human musculoskeletal system have been well accepted, less attention has been paid by researchers to the relevance of cigarette smoke to the onset of osteoarthritis (OA). Here, we investigated the effects of cigarette smoke extract (CSE) on human primary chondrocyte function. In addition, we investigated whether the pharmacologic treatment of dexamethasone was beneficial to chondrocytes impaired by CSE, and if not, whether it could be substituted by other...
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