Morphological profiling of environmental chemical combinations - images, pipelines, and features

Jonne Rietdijk, Tanya Aggarwal, Polina Georgiev, Maris Lapins, Jordi Carreras-Puigvert & Ola Spjuth
Abstract: Environmental chemicals are commonly studied one at a time, and there is a need to advance our understanding of the effect of exposure to their combinations. Here we apply high-content microscopy imaging of cells stained with multiplexed dyes (Cell Painting) to profile the effects of Cetyltrimethylammonium bromide (CTAB), Bisphenol A (BPA), and Dibutyltin dilaurate (DBTDL) exposure on four human cell lines; both individually and in all combinations. We show that morphological features can...
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