Effect of metformin on growth of differentiated thyroid cells and thyroid carcinoma cells and their derived cancer stem cells

Guofang Chen
Insulin resistance and consecutive hyperinsulinemia and are the major reasons for a higher prevalence of several cancer entities in type 2 diabetes mellitus and obesity. Insulin exerts its growth-promoting effect via activation of insulin receptor- and insulin-like growth factor (IGF) receptor-dependent signaling. Metformin, an oral anti-diabetic drug, exerts a growth-inhibitory effect by reducing hyperinsulinemia and by a direct cellular action. This dual mode of metformin action is the rationale to consider metformin as a potential...
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