Toward a porcinein vivomodel to analyze the pathogenesis of TLR5-dependent enteropathies

Robert Pieper, Niels Van Best, Kira Van Vorst, Friederike Ebner, Monika Reissmann, Mathias W. Hornef & Marcus Fulde
Non-communicable diseases, such as the metabolic syndrome and inflammatory bowel disease, constitute serious public health threats in developed countries. Besides environmental factors, genetic predispositions contribute to the onset and progression of the disease.State-of-the-artmouse models recently highlight the involvement of Toll-like receptor 5 (TLR5)-driven microbiota composition in the development of metabolic disorders. Here, we discuss the causes and consequences of an altered enteric microbiota and provide information on a similar mechanism in another species, the pig....
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