Biochemical and functional characterization of the Pch2/ORC AAA+ assembly in controlling meiotic DNA break formation

Maria Ascension Villar Fernandez
Programmed DNA double-strand break (DSB) formation followed by homologous crossover recombination is crucial to establish physical linkages between homologous chromosomes and to ensure faithful chromosome segregation during meiosis. However, the introduction of DSBs within repetitive DNA elements is a major source of genomic instability, due to the possibility of DSBs repairing by non-allelic homologous recombination (NAHR). Indeed, DSBs in such repetitive regions can cause genome rearrangements and chromosome missegregation, which is linked to several genetic...
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