Adipokines and melanocortins in the hepatic manifestation of metabolic syndrome: nonalcoholic fatty liver disease

Mohammed Jarrar
Metabolic syndrome is associated with nonalcoholic fatty liver disease and its moreaggressive form, nonalcoholic steatohepatitis. Adipokines produced by white adipose tissue possess broad physiological activity and play an important autocrine role in obesity-associated complications, including metabolic syndrome, nonalcoholic fatty liverdisease and cardiovascular disease. Various adipokines may have beneficial or harmfuleffects. Other tissues, particularly stomach and intestine, produce active molecules thatcan influence the function of adipocytes and, possibly, the levels of adipokine secretion. Insome cases, the...
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