Often claimed, rarely tested: differences in individual drug response

Stephanie Winkelbeiner, Stefan Leucht, John Kane & Philipp Homan
It is a widely held belief that patients with schizophrenia vary considerably in their response to antipsychotics in randomized controlled trials. In this project, we assumed that the overall variation due to individual treatment response (present in the treatment group) can be separated from random variation (present in the treatment and control group) by comparing the variability between groups. Thus, a personal element of response should be reflected by a clinically relevant increase in overall...
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