Cytochrome P450 Derived Eicosanoids, Endothelial Function and Cardiovascular Disease

Endothelial dysfunction plays an integral role in the pathogenesis and progression of cardiovascular disease in humans. The development of endothelial dysfunction has been primarily ascribed to functional impairments in nitric oxide biosynthesis. However, arachidonic acid metabolism by the cyclooxygenase and cytochrome P450 epoxygenase pathways also appears to regulate endothelial function. Consequently, genetic variation in these pathways may be important modifiers of cardiovascular disease risk in humans. The collective objective of the studies outlined in this...
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