Examination of Cortical/Thalamic-Striatal Circuitry in Modulating Sensitivity to Alcohol and Relapse

All drugs of abuse produce unique interoceptive/subjective (i.e., discriminative stimulus) effects that can impact drug-taking, seeking, and relapse in both clinical and pre-clinical studies. However, the neural circuitry modulating the interoceptive effects of alcohol has yet to be established. The nucleus accumbens core (AcbC), a region known to modulate alcohol-related behaviors, also plays a central role in modulating the discriminative stimulus effects of alcohol. Thus, by investigating the insular cortex (IC) and rhomboid thalamic nucleus...
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