Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: A role for NMDA receptors

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The neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone or ALLO) positively modulates GABAA receptors, an action that may contribute to the anxiolytic effects of ALLO. Recent evidence suggests that ALLO’s anxiolytic effects appear to be mediated by the amygdala, a key neural structure for emotional and cognitive behaviors. However, little is known regarding ALLO effects on amygdala physiology. We therefore explored ALLO effects on GABA neurotransmission in the central nucleus (Ce) of the amygdala, a major output nucleus involved...
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