Methods for high-throughput analysis of RNA structure and dynamics

RNA sequences fold back on themselves to form secondary and tertiary structures that are difficult to predict. Knowledge of these structures and the time-resolved mechanism by which RNA molecules fold into these structures are necessary for a full understanding of structure-function relationships in RNA biology. A newly developed technology, called SHAPE, provides accurate and quantitative RNA structure information. SHAPE chemistry was developed using N-methylisatoic anhydride (NMIA), which is only moderately electrophilic and requires tens of...
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