Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection

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Pediatric HIV infection remains a global health crisis with a worldwide infection rate of 2.5 million (WHO, Geneva Switzerland, 2009). Children are much more susceptible to HIV-1 neurological impairments than adults, which is exacerbated by co-infections. A major obstacle in pediatric HIV research is sample access. The proposed studies take advantage of ongoing pediatric SIV pathogenesis and vaccine studies to test the hypothesis that pediatric SIV infection diminishes neuronal populations and neurogenesis in the hippocampus....
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