THE ROLE OF ACYL-COA SYNTHETASE-MEDIATED FATTY ACID METABOLISM IN METABOLIC MYOPATHY AND ATHEROSCLEROSIS

Long chain acyl-CoA synthetases (ACSLs), and very long chain acyl-CoA synthetases (ACSVLs) which are also known as fatty acid transporters (FATPs), initiate long chain fatty acid (LCFA) oxidation through activation of LCFA by thiol-esterification. Impaired fatty acid oxidation (FAO) can cause metabolic myopathy; however, the underlying mechanisms by which FAO impairment contributes to the pathogenesis of myopathy remain obscure. Compared to control mice (Acsl1flox/flox), Acsl1M-/- mice had 3.4- and 1.5-fold higher plasma creatine kinase (CK)...
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