Maternal Ube3a is Required for Neurotypical Motivational Drive and GABA co-release

Dopaminergic projections from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) are known to be critical players in motivated, reward-seeking behaviors and are involved in learning processes during positive-reinforcement. These neurons co-release several neurotransmitters in the NAc, however; their differential role in motivation and positive-reinforcement is unknown. Angelman syndrome (AS) is a neurodevelopmental disorder caused by the deletion or mutation of the E3-ubiquitin ligase, Ube3a. Ube3a is monoallelically expressed from the maternal allele...
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