Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

, , , , , , , , , , , , &
Highly selective monoclonal antibodies recognizing the extracellular 3D epitope of G protein-coupled receptors represent valuable tools for elucidating receptor function and localization in the cell and show promise for a range of therapeutic applications. Here we present the structure of a complex between the human serotonin 2B receptor, captured in an active-like state, and an antibody Fab fragment, bound to the extracellular side of the receptor. The structure uncovers the mechanisms of receptor activation and...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.