Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats

, , , , , &
Selective serotonin reuptake inhibitor (SSRI) antidepressants are the mainstay treatment for the 10–20% of pregnant and postpartum women who suffer major depression, but the effects of SSRIs on their children’s developing brain and later emotional health are poorly understood. SSRI use during pregnancy can elicit antidepressant withdrawal in newborns and increase toddlers’ anxiety and social avoidance. In rodents, perinatal SSRI exposure increases adult depression- and anxiety-like behavior, although certain individuals are more vulnerable to these...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.