Seeing Is Believing: The Stalk Intermediate

Membrane biophysicists have sought the molecular nature of biomembrane fusion for more than 30 years. In this time, two conflicting hypotheses have evolved to explain very different observations. One, based on electrophysiological measurements on patch-clamped cells (1), is the proteinacious pore hypothesis. This model, popular among neurobiologists, contends that the initial fusion pore consists of a single proteinacious channel that later opens into a full fusion pore due to dissipation of the initial protein pore...
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