The Involvement of Receptor Interacting Protein Kinase 1 (RIPK1) in the Pathogenesis of Acute Pancreatitis

Y Ouyang
Acute pancreatitis (AP) is a severe and potentially fatal human disease characterized by parenchymal necrosis with associated inflammation. Necroptosis is a form of controlled necrosis which is mediated through receptor interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like protein (MLKL) as a regulated cell death pathway. Accumulating studies have demonstrated that necroptosis plays an important role in the pathogenesis of AP related to RIPK3 and MLKL. However, the function of RIPK1 in...
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