The Effects of Hypoxic Preconditioning on the Oxygenation and Metabolic Profile of Neuroblastoma

Y Almutawa
Despite neuroblastoma being the most common extracranial solid malignancy in children, it presents a significantly atypical challenge to clinicians and researchers due to its complex biological interplay and heterogeneous behaviour. Hypoxia, which is a lack of oxygenation, has been implicated as a significant factor leading to metastasis, treatment resistance and poor prognosis in many cancers, including neuroblastoma. Whilst our lab has previously demonstrated that hypoxic pre-conditioning of neuroblastoma cells directly triggers neuroblastoma tumour metastasis, it...
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