Implementing computational techniques to investigate immune-mediated adverse drug reactions

G Ghattaoraya
The highly polymorphic human leukocyte antigens are an important player in the immune response against pathogens. However, the variability can also cause problems to patients, clinicians and drug manufacturers due to the phenomenon of immunologically based adverse drug reactions (ADRs) where the interaction between the drug and antigen presenting proteins can interfere with the body’s ability to recognise host cells leading the immune system to mount a response against the host. The underlying mechanisms by...
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